376 papers
This study utilizes cryo-EM to reveal the structural dynamics of transcription-translation coupling in *E. coli*, demonstrating how the flexibility of NusG and NusA accommodates ribosome conformational changes during translation and how steric clashes in collided complexes inhibit ribosome movement and trigger transcription termination.
Despite previous reports linking TTC22 to colon adenocarcinoma metastasis in humans, this study demonstrates that CRISPR-Cas9-mediated inactivation of the Ttc22 gene in C57BL/6N mice results in no observable phenotypic abnormalities, including normal development, fertility, and tumor incidence.
This study reveals that KMT2D deficiency accelerates chondrocyte hypertrophy and senescence in Kabuki syndrome type 1 by increasing mitochondrial ROS production, a process that can be mitigated by ROS neutralization or hypoxia to restore normal bone growth.
This study demonstrates that a lipid nanoparticle-delivered circRNA encoding an engineered human-like uricase effectively and safely lowers serum urate levels for extended periods in a mouse model of hyperuricemia, offering a promising long-term therapeutic strategy for the condition.
This study demonstrates that intensive fishing pressure induces distinct DNA methylation patterns in the marine fish *Xyrichtys novacula* even in genetically homogeneous populations, suggesting that epigenetic mechanisms may facilitate rapid adaptation to anthropogenic selection independently of genetic evolution or age-truncation effects.
This paper provides a comprehensive statistical analysis of the "Einstein from noise" phenomenon, demonstrating that aligning and averaging pure noise against a template causes the estimator's Fourier phases and magnitudes to converge to those of the template, thereby revealing the mechanism behind this model bias and warning of its pitfalls in template matching across scientific disciplines.
This study demonstrates that using pulsed electron illumination on a cryo-EM microscope does not statistically reduce radiation damage or increase the critical dose for biological macromolecules compared to conventional random illumination.
This study demonstrates that while mammalian Pabpc4 is non-essential for development, its loss significantly impacts post-natal growth, survival, and haematopoiesis by causing microcytic anaemia through non-cell-autonomous mechanisms, highlighting critical differences between mammalian and non-mammalian PABPC functions.
This study reveals that caloric restriction engages clock-aligned, anticipatory metabolic control that enhances metabolic health and circadian rhythmicity, whereas fasting-refeeding cycles rely on passive nutrient cues that disrupt these rhythms and lead to metabolic dysfunction.
This study reveals that N6-methyladenosine (m6A) RNA methylation in *Aedes albopictus* cells restricts Zika virus replication by suppressing the expression of specific serine proteases, thereby identifying a critical epitranscriptomic mechanism governing mosquito-virus interactions.
This study proposes a molecular-based functional classification strategy for fetal bovine serum (FBS) using transcriptomic and cytokine profiling, demonstrating that this approach is more reliable for assessing batch performance and predicting functional outcomes than traditional methods relying on geographical origin or Certificate of Analysis parameters.
This study reveals that while spatial gene expression along the proximal-distal axis of adult tibialis anterior muscle is not driven by DNA methylation, sex-specific epigenetic programs characterized by widespread male hypermethylation serve as the primary determinant of methylation variation and associated transcriptional differences.
This study demonstrates that extracellular vesicles isolated from boar artificial insemination doses retain structural integrity, carry fertility-predictive protein and miRNA signatures that distinguish high- and low-fertility boars, and functionally modulate sperm physiology to improve quality and reduce oxidative stress.
This study demonstrates that recruiting Casein kinase I (CSNK1) family members to oncogenic β-catenin via induced-proximity strategies triggers kinase-dependent, proteasome-mediated degradation of β-catenin, thereby inhibiting the growth of colorectal cancer cells with Wnt pathway mutations.
This study elucidates the molecular mechanism by which the human methyltransferase NSUN2 recognizes and modifies tRNA substrates, revealing that it remodels the tRNA's L-shaped architecture to access the target cytidine and demonstrating how a specific disease-associated mutation (Gly679Arg) disrupts this essential complex.
This study demonstrates that combining the alpha-synuclein aggregation inhibitor anle138b with the ER stress inhibitor AMG PERK 44 significantly enhances neuroprotection in a Parkinson's disease organoid model by improving metabolic activity, reducing alpha-synuclein pathology and cell death, and restoring proteostasis.
This study demonstrates that the cardiomyocyte-enriched protein FYCO1 mitigates post-ischemic cardiac remodeling and preserves heart function by enhancing autophagic flux and suppressing pro-inflammatory signaling following myocardial infarction.
This study reveals a positive feedback loop in which GABARAP, a member of the mATG8 family, directly binds to and activates the PtdIns3K-C1 complex to boost PtdIns3P production, thereby accelerating phagophore nucleation and enabling the rapid expansion of autophagosomes during starvation.
The paper introduces EVA, a long-context generative foundation model trained on over 114 million full-length RNA sequences that leverages a Mixture-of-Experts architecture to achieve state-of-the-art performance in deciphering RNA design principles and enabling versatile, controllable sequence engineering across diverse RNA classes.
The paper introduces OmniBind, a fast message-passing neural network that predicts small-molecule promiscuity across the entire human proteome to enable more effective early-stage drug screening by prioritizing compounds with high specificity over those with high target affinity alone.